https://novaprd-lb.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Quantitative analysis of immunolabeling for serotonin and for glutamate transporters after administration of imipramine and citalopram https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:666 Thu 25 Jul 2013 09:10:21 AEST ]]> Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:1898 440 msec. Results: There were 469 SSRI poisoning admissions analyzed after exclusions. The median LOS for all SSRI overdose admissions was 15.3 h (IQR: 10.5–21.3) and 30 of 469 (6.4%; 95% CI 4.3–9.0%) cases were admitted to ICU. The incidence of seizures was 1.9% and coma was 2.4%. Serotonin syndrome occurred in 14% of overdoses. Comparison of median QTc intervals of the five SSRIs was significantly different (p = 0.0002); citalopram (450 IQR: 436–484) was individually different to fluoxetine (p = 0.045), fluvoxamine (p = 0.022), paroxetine (p = 0.0002), and sertraline (p = 0.001). The proportion of citalopram overdoses with a QTc > 440 msec was 68%, differing significantly from sertraline (adjusted OR: 5.11 95% CI 2.32–11.27). Comparison of median QT intervals of the five SSRIs was statistically different (p = 0.026); citalopram (400 IQR: 380–440) was individually different from sertraline (p = 0.023). Conclusions: This study shows SSRIs are relatively safe in overdose despite serotonin syndrome being common. The exception was citalopram, which was significantly associated with QTc prolongation. We believe that cardiac monitoring should be considered in citalopram overdose, particularly with large ingestions and patients with associated cardiac disease.]]> Sat 24 Mar 2018 08:33:08 AEDT ]]> A critical review of the mechanism of action for the selective serotonin reuptake inhibitors: do these drugs possess anti-inflammatory properties and how relevant is this in the treatment of depression? https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:19925 Sat 24 Mar 2018 08:03:47 AEDT ]]> A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:23164 Sat 24 Mar 2018 07:10:28 AEDT ]]> Factors contributing to serotonin toxicity https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:32719 Mon 23 Sep 2019 13:35:30 AEST ]]>