https://novaprd-lb.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Heritable defects in telomere and mitotic function selectively predispose to sarcomas https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:50526 Wed 28 Feb 2024 15:27:25 AEDT ]]> The role of the retinoids in schizophrenia: genomic and clinical perspectives https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:40464 Wed 27 Jul 2022 13:10:26 AEST ]]> Pairwise common variant meta-analyses of schizophrenia with other psychiatric disorders reveals shared and distinct gene and gene-set associations https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:45203 0.05). Multivariable gene-set association suggested that common variation enrichment within biologically constrained genes observed for schizophrenia also occurs across several psychiatric phenotypes. Pairwise meta-analysis of schizophrenia and each psychiatric phenotype was implemented and identified 330 significantly associated genes (PMeta < 2.7 × 10−6) that were only nominally associated with each disorder individually (P < 0.05). These analyses consolidate the overlap between the genomic architecture of schizophrenia and other psychiatric disorders, uncovering several candidate pleiotropic genes which warrant further investigation.]]> Wed 26 Oct 2022 14:40:02 AEDT ]]> Epigenomic dysregulation in schizophrenia: in search of disease etiology and biomarkers https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:45103 Wed 26 Oct 2022 13:14:01 AEDT ]]> Super-enhancers in transcriptional regulation and genome organization https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:45083 cis-regulatory elements and their associated trans-acting factors. Where these components aggregate in promoters and enhancers, they are able to cooperate to modulate chromatin structure and support the engagement in long-range 3D superstructures that shape the dynamics of a cell's genomic architecture. Recently, the term 'super-enhancer' has been introduced to describe a hyper-active regulatory domain comprising a complex array of sequence elements that work together to control the key gene networks involved in cell identity. Here, we survey the unique characteristics of super-enhancers compared to other enhancer types and summarize the recent advances in our understanding of their biological role in gene regulation. In particular, we discuss their capacity to attract the formation of phase-separated condensates, and capacity to generate three-dimensional genome structures that precisely activate their target genes. We also propose a multi-stage transition model to explain the evolutionary pressure driving the development of super-enhancers in complex organisms, and highlight the potential for involvement in tumorigenesis. Finally, we discuss more broadly the role of super-enhancers in human health disorders and related potential in therapeutic interventions.]]> Wed 26 Oct 2022 12:02:41 AEDT ]]> Extension of mRNA poly(A) tails and 3 ' UTRs during neuronal differentiation exhibits variable association with post-transcriptional dynamics https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:53361 Wed 22 Nov 2023 12:59:24 AEDT ]]> The genetic architecture of the human cerebral cortex https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:42676 Wed 22 Mar 2023 14:34:07 AEDT ]]> Interactive effects of polygenic risk and cognitive subtype on brain morphology in schizophrenia spectrum and bipolar disorders https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:51035 Wed 16 Aug 2023 10:17:09 AEST ]]> Cell type-specific manifestations of cortical thickness heterogeneity in schizophrenia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:47091 Wed 14 Dec 2022 09:37:26 AEDT ]]> Genetic markers of human evolution are enriched in schizophrenia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:25928 −9) more prevalent in genomic regions that are likely to have undergone recent positive selection in humans (i.e., with a low NSS score). Variants in brain-related genes with a low NSS score confer significantly higher susceptibility than variants in other brain-related genes. The enrichment is strongest for schizophrenia, but we cannot rule out enrichment for other phenotypes. The false discovery rate conditional on the evolutionary proxy points to 27 candidate schizophrenia susceptibility loci, 12 of which are associated with schizophrenia and other psychiatric disorders or linked to brain development. Conclusions: Our results suggest that there is a polygenic overlap between schizophrenia and NSS score, a marker of human evolution, which is in line with the hypothesis that the persistence of schizophrenia is related to the evolutionary process of becoming human.]]> Wed 12 Aug 2020 09:42:59 AEST ]]> Derivation of poly-methylomic profile scores for schizophrenia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:39125 p-value thresholds by summing methylation beta-values weighted by individual-CpG effect sizes from the meta-analysis of a previously published schizophrenia EWAS (comprising three separate cohorts with 675 [353 SZ and 322 HC] discovery cohort participants, 847 [414 SZ and 433 HC] replication cohort participants, and 96 monozygotic twin-pairs discordant for SZ). All SZ PMPSs were elevated in SZ participants relative to HCs, with the score calculated at a p-value threshold of 1 x 10⁻⁵ accounting for the greatest amount of variance. All PMPSs were elevated in SZ relative to BD and none of the PMPSs were increased in BD, or in a combined cohort of BD and SZ cases, relative to HCs. PMPSs were also not associated with positive or negative symptom severity. That this SZ-derived PMPSs was elevated in SZ, but not BD, suggests that epigenome-wide methylation patterns may represent distinct pathophysiology that is yet to be elucidated.]]> Wed 11 May 2022 14:56:34 AEST ]]> Upregulation of dicer and MicroRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:11770 Wed 11 Apr 2018 17:17:57 AEST ]]> Leveraging genomic annotations and pleiotropic enrichment for improved replication rates in schizophrenia GWAS https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:26719 -8). There were 693 and 219 independent loci with model-based replication rates ≥80% and ≥90%, respectively. Compared to analyses not incorporating relative enrichment scores, CM3 increased out-of-sample yield for SNPs that replicate at a given rate. This demonstrates that replication probabilities can be more accurately estimated using prior enrichment information with CM3.]]> Wed 11 Apr 2018 17:05:48 AEST ]]> Advances in non-coding RNA profiling for neurological diseases https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:21388 Wed 11 Apr 2018 16:23:56 AEST ]]> Multivariate neuroanatomical classification of cognitive subtypes in schizophrenia: a support vector machine learning approach https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:19873 Wed 11 Apr 2018 15:32:27 AEST ]]> Regulation of gene expression by microRNA in HCV infection and HCV-mediated hepatocellular carcinoma https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:16766 Wed 11 Apr 2018 15:18:46 AEST ]]> Ontogeny of small RNA in the regulation of mammalian brain development https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:15763 Wed 11 Apr 2018 15:11:49 AEST ]]> Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case-control sample of schizophrenia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:23292 Wed 11 Apr 2018 15:09:07 AEST ]]> Noncoding RNA regulation of dopamine signaling in diseases of the central nervous system https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:25334 Wed 11 Apr 2018 15:03:48 AEST ]]> Antipsychotic drug-associated gene-miRNA interaction in T-lymphocytes https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:18037 Wed 11 Apr 2018 14:27:24 AEST ]]> Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:14892 Wed 11 Apr 2018 13:50:23 AEST ]]> MicroRNA dysregulation in schizophrenia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:20377 Wed 11 Apr 2018 13:30:31 AEST ]]> Inhibition of extracellular matrix mediated TGF-β signalling suppresses endometrial cancer metastasis https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:30784 Wed 11 Apr 2018 13:21:37 AEST ]]> Primer fabrication using polymerase mediated oligonucleotide synthesis https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:7836 Wed 11 Apr 2018 12:59:01 AEST ]]> MicroRNA: small RNA mediators of the brains genomic response to environmental stress https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:29331 Wed 11 Apr 2018 12:30:03 AEST ]]> MicroRNA-16 is down-regulated in mutated FLT3 expressing murine myeloid FDC-P1 cells and interacts with Pim-1 https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:15110 Wed 11 Apr 2018 11:57:39 AEST ]]> RNA modulators of complex phenotypes in mammalian cells https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:7723 Wed 11 Apr 2018 11:43:25 AEST ]]> Alternative mRNA fates identified in microRNA-associated transcriptome analysis https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:15192 Wed 11 Apr 2018 11:39:00 AEST ]]> MicroRNA and posttranscriptional dysregulation in psychiatry https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:27379 Wed 11 Apr 2018 09:45:10 AEST ]]> Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:15118 Wed 11 Apr 2018 09:18:27 AEST ]]> miRNA enriched in human neuroblast nuclei bind the MAZ transcription factor and their precursors contain the MAZ consensus motif https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:33472 Wed 04 Sep 2019 09:48:55 AEST ]]> Protocol for high-throughput miRNA profiling of the rat brain https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:30115 Wed 04 Oct 2017 12:46:07 AEDT ]]> Alteration of DNA Methylation and Epigenetic Scores Associated with Features of Schizophrenia and Common Variant Genetic Risk https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:55024 Wed 03 Apr 2024 15:41:54 AEDT ]]> Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:24541 Wed 02 Mar 2022 14:27:14 AEDT ]]> Data analysis guidelines for single-cell RNA-seq in biomedical studies and clinical applications https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:52015 Tue 26 Sep 2023 11:42:58 AEST ]]> The maternal immune activation model uncovers a role for the Arx gene in GABAergic dysfunction in schizophrenia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:44959 Arx gene, critical to healthy neurodevelopment of PV interneurons, is reduced in the forebrain of MIA exposed mice. Finally, in a whole-genome sequenced patient cohort, we identified a novel missense mutation of ARX in a patient with schizophrenia and in the Psychiatric Genomics Consortium 2 cohort, a nominal association of proximal ARX SNPs with the disorder. This suggests MIA, as a risk factor for schizophrenia, may be influencing Arx expression to induce the GABAergic dysfunction seen in schizophrenia and that the ARX gene may play a role in the prenatal origins of schizophrenia pathophysiology.]]> Tue 25 Oct 2022 12:28:24 AEDT ]]> Small RNA regulators of social behaviour in eutherian mammals https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:47678 EMBO Reports, Lackinger et al demonstrate that a large cluster of miRNAs, that emerged in placental mammals, functions as a repressor of social behaviour. This discovery has significant implications for our understanding of the brain, behaviour and in particular psychiatric syndromes, which have been shown to display alterations of these molecules.]]> Tue 24 Jan 2023 16:30:14 AEDT ]]> Discovering functional microRNA-mRNA regulatory modules in heterogeneous data https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:18195 Tue 23 Jun 2015 18:36:12 AEST ]]> Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:44746 Tue 21 Mar 2023 16:53:58 AEDT ]]> Schizophrenia-associated MicroRNA–Gene Interactions in the Dorsolateral Prefrontal Cortex https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:45935 Tue 08 Nov 2022 10:00:10 AEDT ]]> MicroRNA binding site variation is enriched in psychiatric disorders https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:50575 Tue 01 Aug 2023 09:52:01 AEST ]]> Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:40024 Thu 21 Jul 2022 09:47:00 AEST ]]> Investigation of glycaemic traits in psychiatric disorders using Mendelian randomisation revealed a causal relationship with anorexia nervosa https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:49464 Thu 18 May 2023 14:19:57 AEST ]]> Temporally specific miRNA expression patterns in the dorsal and ventral striatum of addiction-prone rats https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:36090 Thu 17 Mar 2022 14:39:03 AEDT ]]> Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:47202 Thu 15 Dec 2022 11:18:18 AEDT ]]> A polygenic resilience score moderates the genetic risk for schizophrenia: Replication in 18,090 cases and 28,114 controls from the Psychiatric Genomics Consortium https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:54811 Thu 14 Mar 2024 14:24:56 AEDT ]]> Gene set enrichment analysis of RNA-Seq data: integrating differential expression and splicing https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:14818 Thu 12 Apr 2018 13:24:24 AEST ]]> Pharmacological enrichment of polygenic risk for precision medicine in complex disorders https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:41990 Thu 10 Aug 2023 12:12:50 AEST ]]> PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:55040 Thu 04 Apr 2024 13:51:52 AEDT ]]> Identification of gene loci that overlap between schizophrenia and educational attainment https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:34615 Thu 04 Apr 2019 09:04:20 AEDT ]]> miR-518f-5p decreases tetraspanin CD9 protein levels and differentially affects non-tumourigenic prostate and prostate cancer cell migration and adhesion https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:33474 Thu 03 Feb 2022 12:18:02 AEDT ]]> Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:7882 Sat 24 Mar 2018 08:41:34 AEDT ]]> The DNA sequence selectivity of maltolato-containing cisplatin analogues in purified plasmid DNA and in intact human cells https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:7080 Sat 24 Mar 2018 08:37:57 AEDT ]]> Substituted 9-aminoacridine-4-carboxamides tethered to platinum(II)diamine complexes: Chemistry, cytotoxicity and DNA sequence selectivity https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:9530 Sat 24 Mar 2018 08:35:32 AEDT ]]> Recent patents in antiviral siRNAs https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:11111 Sat 24 Mar 2018 08:12:25 AEDT ]]> Expression of NPAS3 in the human cortex and evidence of its posttranscriptional regulation by miR-17 during development, with implications for schizophrenia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:19034 Sat 24 Mar 2018 08:05:26 AEDT ]]> Catechol-O-methyltransferase (COMT) genotype moderates the effects of childhood trauma on cognition and symptoms in schizophrenia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:21387 Catechol-O-methyltransferase (COMT) Val¹⁵⁸Met polymorphism, a common genetic variant known to affect cognition and prefrontal dopamine levels. Participants were 429 schizophrenia/schizoaffective cases from the Australian Schizophrenia Research Bank (ASRB). Cognitive performance was assessed using the Repeatable Battery for Assessment of Neuropsychological Status (RBANS), Controlled Oral Word Association Test (COWAT), Letter Number Sequencing (LNS) test, and the Wechsler Test of Adult Reading (WTAR). Hierarchical regression was used to test the main effects and additive interaction effects of genotype and childhood trauma in the domains of physical abuse, emotional abuse, and emotional neglect, on cognition and symptom profiles of clinical cases. Consistent with previous findings, COMT Val homozygotes performed worse on cognitive measures in the absence of childhood adversity. In addition, a significant interaction between COMT genotype and physical abuse was associated with better executive function in Val homozygotes, relative to those of the same genotype with no history of abuse. Finally, the severity of positive symptoms was greater in Met carriers who had experienced physical abuse, and the severity of negative symptoms in Met carriers was greater in the presence of emotional neglect. These results suggest that the possible epigenetic modulation of the expression of the COMT Val¹⁵⁸Met polymorphism and consequent effects on cognition and symptoms in schizophrenia, with worse outcomes associated with adverse childhood experiences in Met carriers.]]> Sat 24 Mar 2018 08:05:04 AEDT ]]> Post-transcriptional trafficking and regulation of neuronal gene expression https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:18237 Sat 24 Mar 2018 08:04:53 AEDT ]]> Identifying miRNAs, targets and functions https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:20860 Sat 24 Mar 2018 08:02:52 AEDT ]]> Design and interpretation of microRNA-reporter gene activity https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:20136 Sat 24 Mar 2018 07:51:34 AEDT ]]> Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:20133 Sat 24 Mar 2018 07:51:34 AEDT ]]> Gene-microRNA interactions associated with antipsychotic mechanisms and the metabolic side effects of olanzapine https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:20134 Sat 24 Mar 2018 07:51:33 AEDT ]]> Context-specific microRNA function in developmental complexity https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:20135 Sat 24 Mar 2018 07:51:32 AEDT ]]> Dysregulation of miRNA 181b in the temporal cortex in schizophrenia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:5407 Sat 24 Mar 2018 07:48:18 AEDT ]]> Do common genotypes of FK506 binding protein 5 (FKBP5) moderate the effects of childhood maltreatment on cognition in schizophrenia and healthy controls? https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:26307 Sat 24 Mar 2018 07:40:40 AEDT ]]> Proteotranscriptomic profiling of 231-BR breast cancer cells: identification of potential biomarkers and therapeutic targets for brain metastasis https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:28878 Sat 24 Mar 2018 07:40:30 AEDT ]]> CX3CR1 is dysregulated in blood and brain from schizophrenia patients https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:27390 Sat 24 Mar 2018 07:34:09 AEDT ]]> Alteration of transcriptional networks in the entorhinal cortex after maternal immune activation and adolescent cannabinoid exposure https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:30081 Sat 24 Mar 2018 07:31:17 AEDT ]]> Schizophrenia risk from complex variation of complement component 4 https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:30050 Sat 24 Mar 2018 07:31:15 AEDT ]]> Optimal consistency in microRNA expression analysis using reference-gene-based normalization https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:26724 Sat 24 Mar 2018 07:26:21 AEDT ]]> Altered neural signaling and immune pathways in peripheral blood mononuclear cells of schizophrenia patients with cognitive impairment: a transcriptome analysis https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:25081 Sat 24 Mar 2018 07:15:04 AEDT ]]> A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:23164 Sat 24 Mar 2018 07:10:28 AEDT ]]> Post-Transcriptional Mechanisms of Neuronal Translational Control in Synaptic Plasticity https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:50796 Sat 05 Aug 2023 14:24:49 AEST ]]> Linking Polygenic Risk of Schizophrenia to Variation in Magnetic Resonance Imaging Brain Measures: A Comprehensive Systematic Review https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:53905 Mon 22 Jan 2024 15:11:18 AEDT ]]> The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:42338 N = 29,125 cases and 34,836 controls), a robust polygenic signal was observed from gene sets based on TCF4, FMR1, upregulation from MIR137 and downregulation from CHD8. Additional analyses revealed a constant floor effect in the amount of variance explained, consistent with the omnigenic model. Thus, we report that putative core gene sets showed a significant effect above and beyond the floor effect that might be linked with the underlying omnigenic background. In addition, we demonstrate a method to quantify the contribution of specific gene sets within the omnigenic context.]]> Mon 22 Aug 2022 14:00:20 AEST ]]> Understanding complex transcriptome dynamics in schizophrenia and other neurological diseases using RNA sequencing https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:18698 Mon 20 Jul 2015 17:48:12 AEST ]]> A polygenic resilience score moderates the genetic risk for schizophrenia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:38229 Mon 16 Aug 2021 17:39:39 AEST ]]> Evidence of genetic overlap and causal relationships between blood-based biochemical traits and human cortical anatomy https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:50979 Mon 14 Aug 2023 15:25:32 AEST ]]> Genetics-informed precision treatment formulation in schizophrenia and bipolar disorder https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:50980 Mon 14 Aug 2023 15:24:38 AEST ]]> Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:50972 Mon 14 Aug 2023 15:19:39 AEST ]]> Perceptions of causal attribution and attitudes to genetic testing among people with schizophrenia and their first-degree relatives https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:50953 Mon 14 Aug 2023 14:36:26 AEST ]]> Pairwise genetic meta-analyses between schizophrenia and substance dependence phenotypes reveals novel association signals with pharmacological significance https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:50935 Mon 14 Aug 2023 12:29:31 AEST ]]> Using Genetics to Inform Interventions Related to Sodium and Potassium in Hypertension https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:55070 Mon 08 Apr 2024 13:27:57 AEST ]]> Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:48305 Mon 01 May 2023 15:23:00 AEST ]]> Circular RNA biogenesis is decreased in postmortem cortical gray matter in schizophrenia and may alter the bioavailability of associated miRNA https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:48732 Fri 31 Mar 2023 09:37:21 AEDT ]]> Mapping genomic loci implicates genes and synaptic biology in schizophrenia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:49672 Fri 26 May 2023 15:35:47 AEST ]]> Oxidative Stress Impact on the Transcriptome of Differentiating Neuroblastoma Cells: Implication for Psychiatric Disorders https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:43551 Fri 23 Sep 2022 10:12:36 AEST ]]> Characterising the transcriptional and translational impact of the schizophrenia-associated miR-1271-5p in neuronal cells https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:37998 Fri 23 Jul 2021 14:30:41 AEST ]]> Depolarization-associated CircRNA regulate neural gene expression and in some cases may function as templates for translation https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:37996 Fri 23 Jul 2021 14:02:51 AEST ]]> Multiomic prioritisation of risk genes for anorexia nervosa https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:53844 Fri 19 Jan 2024 10:17:45 AEDT ]]> Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:47250 Fri 16 Dec 2022 12:29:24 AEDT ]]> Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:51745 Fri 15 Sep 2023 18:22:09 AEST ]]> Exploring opportunities for drug repurposing and precision medicine in cannabis use disorder using genetics https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:51705 Fri 15 Sep 2023 14:03:12 AEST ]]> Small RNA dysregulation in neurocognitive and neuropsychiatric disorders https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:33738 Fri 14 Dec 2018 14:49:06 AEDT ]]> Dysregulation of circRNA expression in the peripheral blood of individuals with schizophrenia and bipolar disorder https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:49352 Fri 12 May 2023 12:21:21 AEST ]]> Alteration of miRNA-mRNA interactions in lymphocytes of individuals with schizophrenia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:37045 Fri 07 Aug 2020 14:34:14 AEST ]]> Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants with Treatment Resistance in Schizophrenia https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:49142 Fri 05 May 2023 12:07:01 AEST ]]> Polygenic risk for schizophrenia as a moderator of associations between childhood trauma and schizotypy https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:51364 Fri 01 Sep 2023 13:45:06 AEST ]]> The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:51343 Fri 01 Sep 2023 13:34:03 AEST ]]> Beyond the Global Brain Differences: Intra-individual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:54564 Fri 01 Mar 2024 11:18:59 AEDT ]]>