https://novaprd-lb.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Role of mitochondria in contraction and pacemaking in the mouse uterus https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:11410 Sat 24 Mar 2018 08:11:11 AEDT ]]> Pacemaker currents in mouse locus coeruleus neurons https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:11513 Sat 24 Mar 2018 08:11:08 AEDT ]]> Control of sarcoplasmic reticulum Ca²⁺ release by stochastic RyR gating within a 3D model of the cardiac dyad and importance of induction decay for CICR termination https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:20204 Sat 24 Mar 2018 08:06:48 AEDT ]]> Termination of calcium-induced calcium release by induction decay: an emergent property of stochastic channel gating and molecular scale architecture https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:20246 2+-dependent gating of ryanodine receptors (RyRs) in the sarco/endoplasmic reticulum (SR) and is critical for cardiac excitation–contraction coupling. This process is seen as Ca2+ sparks, which reflect the concerted gating of groups of RyRs in the dyad, a specialised junctional signalling domain between the SR and surface membrane. However, the mechanism(s) responsible for the termination of regenerative CICR during the evolution of Ca2+ sparks remain uncertain. Rat cardiac RyR gating was recorded at physiological Ca2+, Mg2+ and ATP levels and incorporated into a 3D model of the cardiac dyad which reproduced the time-course of Ca2+ sparks, Ca2+ blinks and Ca2+ spark restitution. Model CICR termination was robust, relatively insensitive to the number of dyadic RyRs and automatic. This emergent behaviour arose from the rapid development and dissolution of nanoscopic Ca2+ gradients within the dyad. These simulations show that CICR does not require intrinsic inactivation or SR calcium sensing mechanisms for stability and cessation of regeneration that arises from local control at the molecular scale via a process we call ‘induction decay’.]]> Sat 24 Mar 2018 07:59:55 AEDT ]]> Multiple modes of ryanodine receptor 2 inhibition by flecainide https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:19544 Sat 24 Mar 2018 07:58:14 AEDT ]]> Ryanodine receptor modification and regulation by intracellular Ca²⁺ and Mg²⁺ in healthy and failing human hearts https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:33274 Mon 24 Sep 2018 13:26:22 AEST ]]>