https://novaprd-lb.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Relationship between levels of pre-stroke physical activity and post-stroke serum insulin-like growth factor I https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:45071 p = 0.06) or as a significant effect (ΔIGF-I, p = 0.03) after all the adjustments. Specifically, for each unit of PA, ΔIGF-I increased by 9.7 (95% CI 1,1−18.4) ng/mL after full adjustment. This supports the notion that pre-stroke PA is independently related to ΔIGF-I.]]> Wed 26 Oct 2022 12:29:03 AEDT ]]> Serum magnesium and calcium levels in relation to ischemic stroke: mendelian randomization study https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:48519 p = 1.3 x 10−4) for all ischemic stroke, 0.63 (95% CI 0.50–0.80; p = 1.6 x 10−4) for cardioembolic stroke, and 0.60 (95% CI 0.44–0.82; p = 0.001) for large artery stroke; there was no association with small vessel stroke (odds ratio 0.90, 95% CI 0.67–1.20; p = 0.46). Only the association with cardioembolic stroke was robust in sensitivity analyses. There was no association of genetically predicted serum calcium concentrations with all ischemic stroke (per 0.5 mg/dL [about 1 SD] increase in serum calcium: odds ratio 1.03, 95% CI 0.88–1.21) or with any subtype. Conclusions: This study found that genetically higher serum magnesium concentrations are associated with a reduced risk of cardioembolic stroke but found no significant association of genetically higher serum calcium concentrations with any ischemic stroke subtype.]]> Wed 22 Mar 2023 17:11:50 AEDT ]]> Species-specific regulation of t-PA and PAI-1 gene expression in human and rat astrocytes https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:20514 Wed 11 Apr 2018 14:06:35 AEST ]]> Serum erythropoietin and outcome after ischaemic stroke: a prospective study https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:30094 Wed 09 Mar 2022 16:00:11 AEDT ]]> PATJ low frequency variants are associated with worse ischemic stroke functional outcome: a genome-wide meta-analysis https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:47651 PATJ (Pals1-associated tight junction) gene were associated with worse functional outcome at 3-month after stroke. The top variant was rs76221407 (G allele, β=0.40, P=1.70x10−9). Conclusions: Our results identify a set of common variants in PATJ gene associated with 3-month functional outcome at genome-wide significance level. Future studies should examine the role of PATJ in stroke recovery and consider stringent phenotyping to enrich the information captured to unveil additional stroke outcome loci.]]> Tue 24 Jan 2023 14:58:40 AEDT ]]> Altered levels of circulating insulin-like growth factor I (IGF-I) following ischemic stroke are associated with outcome - a prospective observational study https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:43109 Tue 13 Sep 2022 13:22:36 AEST ]]> Pathogenic ischemic stroke phenotypes in the NINDS-Stroke Genetics Network https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:19823 Tue 09 Jun 2020 09:48:40 AEST ]]> Genetically determined risk of depression and functional outcome after Ischemic Stroke: mendelian randomization study https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:42205 P=0.06). There was no evidence of heterogeneity between MR estimates produced by different instruments (Q P=0.26). Comparable MR estimates were obtained with weighted median MR (odds ratio, 2.57; 95% CI, 1.05-6.25; P=0.04) and MR pleiotropy residual sum and outlier (odds ratio, 1.81; 95% CI, 0.95-3.46; P=0.08). Conclusions: We found no MR evidence of genetically determined risk of depression affecting ischemic stroke risk but did find consistent MR evidence suggestive of a possible effect on functional outcome after ischemic stroke. Given the widespread prevalence of depression-related morbidity, these findings could have implications for prognostication and personalized rehabilitation after stroke.]]> Thu 25 Aug 2022 11:38:19 AEST ]]> The association of the 4q25 susceptibility variant for atrial fibrillation with stroke is limited to stroke of cardioembolic etiology https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:11142 Sat 24 Mar 2018 08:10:28 AEDT ]]> Genetic variation at the IGF1 locus shows association with post-stroke outcome and to circulating IGF1 https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:28601 IGF1 locus could also associate with both IS and s-IGF1. We investigated whether genetic variation at the IGF1 locus is associated with i) s-IGF1, ii) IS occurrence, iii) IS severity, and iv) post-stroke outcome. Design/methods: Patients (n=844; 66% males, mean age 56 years) and community controls (n=668) were included from the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). Post-stroke outcome was evaluated with the modified Rankin Scale at 3 and 24 months after index stroke, and baseline stroke severity with the Scandinavian Stroke Scale. s-IGF1 was determined in patients and after random selection in 40 of the controls. Results: Eleven single nucleotide polymorphisms (SNPs) were selected in the IGF1 gene. In healthy controls the major allele of rs7136446 was associated with higher s-IGF1, whereas in patients no such association was found. No SNP was associated with IS, nor with stroke severity. After multivariate correction for presence of diabetes, smoking, and hypertension, the major allele of rs7136446 was associated with favorable functional outcome 24-months post-stroke (odds ratio 1.46; 95% CI 1.09–1.96). Conclusion: Variation in rs7136446 of the IGF1 gene associates with post-stroke outcome in relatively young IS patients. Also, rs7136446 associates with s-IGF1 in controls but not in IS, which indicates that IS perturbs a normal genetic impact on s-IGF1 levels.]]> Sat 24 Mar 2018 07:37:28 AEDT ]]> Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:30052 -8; joint OR 1·19, 1·12-1·26, p=1·30 × 10-9). Our results also supported robust associations with ischaemic stroke for four other loci that have been reported in previous studies, including PITX2 (first stage OR 1·39, 1·29-1·49, p=3·26 × 10-19; joint OR 1·37, 1·30-1·45, p=2·79 × 10-32) and ZFHX3 (first stage OR 1·19, 1·11-1·27, p=2·93 × 10-7; joint OR 1·17, 1·11-1·23, p=2·29 × 10-10) for cardioembolic stroke, and HDAC9 (first stage OR 1·29, 1·18-1·42, p=3·50 × 10-8; joint OR 1·24, 1·15-1·33, p=4·52 × 10-9) for large artery atherosclerosis stroke. The 12q24 locus near ALDH2, which has previously been associated with all ischaemic stroke but not with any specific subtype, exceeded genome-wide significance in the meta-analysis of small artery stroke (first stage OR 1·20, 1·12-1·28, p=6·82 × 10-8; joint OR 1·17, 1·11-1·23, p=2·92 × 10-9). Other loci associated with stroke in previous studies, including NINJ2, were not confirmed. Interpretation: Our results suggest that all ischaemic stroke-related loci previously implicated by GWAS are subtype specific. We identified a novel gene associated with large artery atherosclerosis stroke susceptibility.]]> Sat 24 Mar 2018 07:31:15 AEDT ]]> Association between levels of serum insulin-like growth factor I and functional recovery, mortality, and recurrent stroke at a 7-year follow-up https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:38395 146.7 ng/ml). The s-IGF-I level was not associated with recurrent stroke (N=79) or death (N=44), although it correlated with recovery (r=0.12, P=0.035). In the regression analysis, s-IGF-I associated with recovery between 3 months and 7 years (but not between 2 and 7 years). The associations did not withstand adjustment for age and sex. For comparison, the corresponding associations between 3 months and 2 years withstood all adjustments. Conclusion: The association for s-IGF-I with long-term post-stroke recovery persists after 7 years, which is also reflected in the mRS score distributions at all time-points. The effects are however modest, and not driven by mortality or recurrent stroke.]]> Mon 29 Jan 2024 17:47:17 AEDT ]]> Genome-wide association meta-analysis of functional outcome after ischemic stroke https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:48737 Fri 31 Mar 2023 16:23:23 AEDT ]]> Genetic imbalance is associated with functional outcome after Ischemic Stroke https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:42223 P=0.0007; odds ratio=0.89; 95% CI, 0.82–0.95 and SiGN/GISCOME: P=0.0036; odds ratio=0.94; 95% CI, 0.91–0.98). The association was independent of age, sex, stroke severity on admission, stroke subtype, and ancestry. On subgroup analysis, imbalance affecting ohnologs was associated with outcome (CADISP: odds ratio=0.88; 95% CI, 0.80–0.95 and SiGN/GISCOME: odds ratio=0.93; 95% CI, 0.89–0.98) whereas imbalance without ohnologs lacked such an association. Conclusions: Increased genetic imbalance was associated with poorer functional outcome after IS in both study populations. Subgroup analysis revealed that this association was driven by presence of ohnologs in the respective copy number variations, suggesting a causal role of the deleterious effects of genetic imbalance.]]> Fri 26 Aug 2022 09:34:08 AEST ]]>