- Title
- Risk stratification after biochemical failure following curative treatment of locally advanced prostate cancer: data from the TROG 96.01 trial
- Creator
- Steigler, Allison; Denham, James W.; Tai, Keen-Hun; Wynne, Chris; Lamb, David S.; Spry, Nigel A.; Joseph, David; Matthews, John; Atkinson, Chris; Turner, Sandra; North, John; Christie, David
- Relation
- NHMRC.9936572 | 209801 | 455520
- Relation
- Prostate Cancer Vol. 2012, p. 1-11
- Publisher Link
- http://dx.doi.org/10.1155/2012/814724
- Publisher
- Hindawi Publishing
- Resource Type
- journal article
- Date
- 2012
- Description
- Purpose: Survival following biochemical failure is highly variable. Using a randomized trial dataset, we sought to define a risk stratification scheme in men with locally advanced prostate cancer (LAPC). Methods: The TROG 96.01 trial randomized 802 men with LAPC to radiation ± neoadjuvant androgen suppression therapy (AST) between 1996 and 2000. Ten-year follow-up data was used to develop three-tier post-biochemical failure risk stratification schemes based on cutpoints of time to biochemical failure (TTBF) and PSA doubling time (PSADT). Schemes were evaluated in univariable, competing risk models for prostate cancer-specific mortality. The performance was assessed by c-indices and internally validated by the simple bootstrap method. Performance rankings were compared in sensitivity analyses using multivariable models and variations in PSADT calculation. Results. 485 men developed biochemical failure. c-indices ranged between 0.630 and 0.730. The most discriminatory scheme had a high risk category defined by PSADT < 4 months or TTBF < 1 year and low risk category by PSADT > 9 months or TTBF > 3 years. Conclusion: TTBF and PSADT can be combined to define risk stratification schemes after biochemical failure in men with LAPC treated with short-term AST and radiotherapy. External validation, particularly in long-term AST and radiotherapy datasets, is necessary.
- Subject
- prostate cancer; biochemical failure; randomized trial
- Identifier
- http://hdl.handle.net/1959.13/1309167
- Identifier
- uon:21794
- Identifier
- ISSN:2090-312X
- Language
- eng
- Full Text
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