- Title
- Factors in early life programming of reproductive fitness
- Creator
- Sominsky, L.; Fuller, E. A.; Hodgson, D. M.
- Relation
- Neuroendocrinology Vol. 102, Issue 3
- Publisher Link
- http://dx.doi.org/10.1159/000431378
- Publisher
- S. Karger AG
- Resource Type
- journal article
- Date
- 2015
- Description
- Fertility rates have been declining worldwide, with a growing number of young women suffering from infertility. Infectious and inflammatory diseases are important causes of infertility, and recent evidence points to the critical role of the early-life microbial environment in developmental programming of adult reproductive fitness. Our laboratory and others have demonstrated that acute exposure to an immunological challenge early in life has a profound and prolonged impact on male and female reproductive development. This review presents evidence that perinatal exposure to immunological challenge by a bacterial endotoxin, lipopolysaccharide, acts at all levels of the hypothalamic-pituitary-gonadal axis, resulting in long-lasting changes in reproductive function, suggesting that disposition to infertility may begin early in life.
- Subject
- perinatal programming; inflammation; lipopolysaccharide; reproductive development
- Identifier
- http://hdl.handle.net/1959.13/1342061
- Identifier
- uon:28879
- Identifier
- ISSN:0028-3835
- Language
- eng
- Reviewed
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