- Title
- UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng
- Creator
- Zhu, Hailin; Liu, Junli; Lin, Hongqiang; Zhang, Ying; Yang, Na; Zhou, Baisong; Wang, Zhongyao; Chen-Yu Hsu, Alan; Liu, Jinping; Li, Pingya
- Relation
- RSC Advances Vol. 9, Issue 66, p. 38658-38668
- Publisher Link
- http://dx.doi.org/10.1039/c9ra06635g
- Publisher
- Royal Society of Chemistry
- Resource Type
- journal article
- Date
- 2019
- Description
- Four previously undescribed ginsenosides, along with five known analogues were isolated from wild ginseng by a UPLC-QTOF-MS-guided fractionation procedure. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, HR-ESI-MS). The isolated compounds could significantly inhibit the cigarette smoke extract (CSE)-induced inflammatory reaction in A549 cells. The HDAC2 pathway might be involved in the protective effect against the CSE-mediated inflammatory response in A549 cells.
- Subject
- anti-COPD ginsenosides; wild ginseng; cigarette smoke extract (CSE); inflammatory reaction
- Identifier
- http://hdl.handle.net/1959.13/1428903
- Identifier
- uon:38667
- Identifier
- ISSN:2046-2069
- Rights
- This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. http://creativecommons.org/licenses/by/3.0/
- Language
- eng
- Full Text
- Reviewed
- Hits: 5712
- Visitors: 5879
- Downloads: 174
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 1 MB | Adobe Acrobat PDF | View Details Download |