- Title
- Abnormal exercise responses in survivors of acute lung injury during cardiopulmonary exercise testing: an obervational study
- Creator
- Mackney, Jennifer; Harrold, Meg; Jenkins, Sue; Havill, Ken; Hill, Kylie
- Relation
- Journal of Cardiopulmonary Rehabilitation and Prevention Vol. 39, Issue 4, p. E16-E22
- Publisher Link
- http://dx.doi.org/10.1097/HCR.0000000000000432
- Publisher
- Lippincott Williams & Wilkins
- Resource Type
- journal article
- Date
- 2019
- Description
- Purpose: This study compared exercise responses in individuals who had recently survived an admission to the intensive care unit for acute lung injury (ALI) with healthy controls. Methods: Ten patients with ALI were recruited at 2 Australian hospitals. Six weeks after hospital discharge, participants completed lung function measures and a laboratory-based cardiopulmonary exercise test. Identical measures were collected in 21 healthy participants of similar age and gender distribution. Results: Compared with the healthy participants, the ALI participants were similar in age (51 ± 14 vs 50 ± 16 yr), with a lower peak oxygen uptake ((Equation is included in full-text article.)O2) (median [interquartile range], 31.80 [26.60-41.73] vs 17.80 [14.85-20.85] mL/kg/min; P < .01) and higher ventilatory equivalent for carbon dioxide ((Equation is included in full-text article.)E/(Equation is included in full-text article.)CO2) at anaerobic threshold (mean ± SD, 25.7 ± 2.5 vs 35.2 ± 4.1; P < .01). Analysis of individual ALI participant responses showed that 8 participants had a decreased peak (Equation is included in full-text article.)O2 and anaerobic threshold. All ALI participants were limited by leg fatigue. Abnormalities of pulmonary gas exchange were present in 7 participants. Evidence of cardiac ischemia was present in 2 participants. Conclusions: Compared with healthy controls, ALI participants had reduced exercise capacity, mainly due to profound deconditioning. Exercise training to optimize aerobic capacity would appear to be a rehabilitation priority in this population.
- Subject
- acute lung injury; critical illness; exercise test; outcome assessment; survivors
- Identifier
- http://hdl.handle.net/1959.13/1429631
- Identifier
- uon:38730
- Identifier
- ISSN:1932-751X
- Language
- eng
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