Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course

van der Laan, Camiel M.; Morosoli-García, José J.; van de Weijer, Steve G. A.; Colodro-Conde, Lucía; Ip, Hill F.; Krapohl, Eva M. L.; Brikell, Isabell; Sánchez-Mora, Cristina; Nolte, Ilja M.; St Pourcain, Beate; Bolhuis, Koen; Palviainen, Teemu; Zafarmand, Hadi; Gordon, Scott; Zayats, Tetyana; Aliev, Fazil; Jiang, Chang; Wang, Carol A.; Saunders, Gretchen; Karhunen, Ville; Hammerschlag, Anke R.; Pennell, Craig E.

Title: Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course
Creator: van der Laan, Camiel M.; Morosoli-García, José J.; van de Weijer, Steve G. A.; Colodro-Conde, Lucía; Ip, Hill F.; Krapohl, Eva M. L.; Brikell, Isabell; Sánchez-Mora, Cristina; Nolte, Ilja M.; St Pourcain, Beate; Bolhuis, Koen; Palviainen, Teemu; Zafarmand, Hadi; Gordon, Scott; Zayats, Tetyana; Aliev, Fazil; Jiang, Chang; Wang, Carol A.; Saunders, Gretchen; Karhunen, Ville; Hammerschlag, Anke R.; Pennell, Craig E.
Relation: Behavior Genetics Vol. 51, Issue 5, p. 592-606
Publisher Link: http://dx.doi.org/10.1007/s10519-021-10076-6
Publisher: Springer
Resource Type: journal article
Date: 2021
Description: We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12-70 years, Australia: 16-73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a 'rolling weights' model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41-70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life.
Subject: aggressive behavior; aggression; life-course; development; polygenic score; rolling weights
Identifier: http://hdl.handle.net/1959.13/1442974
Identifier: uon:41849
Identifier: ISSN:0001-8244
Language: eng
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