- Title
- A Global Core Outcome Measurement Set for Snakebite Clinical Trials
- Creator
- Abouyannis, Michael; Esmail, Hanif; Alcoba, Gabriel; Cammack, Nick; Chippaux, Jean-Philippe; Coldiron, Matthew E.; Gutiérrez, José M.; Habib, Abdulrazaq G.; Harrison, Robert A.; Isbister, Geoffrey K.; Lavonas, Eric J.; Martins, Diogo; Hamaluba, Mainga; Ribeiro, Isabela; Watson, JA; Williams, DJ; Casewell, NR; Walker, SA; Lalloo, DG; Snakebite Global Core Outcome Set Study Group,; Ngama, Mwanajuma; Mwangudzah, Hope; Mumba, Noni; Yeri, Betty K.; Mwalukore, Salim; Alphan, Hassan J.; Aggarwal, Dinesh
- Relation
- Lancet Global Health Vol. 11, Issue 2, p. e296-e300
- Publisher Link
- http://dx.doi.org/10.1016/S2214-109X(22)00479-X
- Publisher
- Lancet Publishing Group
- Resource Type
- journal article
- Date
- 2023
- Description
- Snakebite clinical trials have often used heterogeneous outcome measures and there is an urgent need for standardisation. A globally representative group of key stakeholders came together to reach consensus on a globally relevant set of core outcome measurements. Outcome domains and outcome measurement instruments were identified through searching the literature and a systematic review of snakebite clinical trials. Outcome domains were shortlisted by use of a questionnaire and consensus was reached among stakeholders and the patient group through facilitated discussions and voting. Five universal core outcome measures should be included in all future snakebite clinical trials-mortality, WHO disability assessment scale, patient-specific functional scale, acute allergic reaction by Brown criteria, and serum sickness by formal criteria. Additional syndrome-specific core outcome measures should be used depending on the biting species. This core outcome measurement set provides global standardisation, supports the priorities of patients and clinicians, enables meta-analysis, and is appropriate for use in low-income and middle-income settings.
- Subject
- snake bites; clinical trials; treatment outcome; global standarisation
- Identifier
- http://hdl.handle.net/1959.13/1481007
- Identifier
- uon:50616
- Identifier
- ISSN:2214-109X
- Rights
- © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article distributed under the terms of the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Language
- eng
- Full Text
- Reviewed
- Hits: 9828
- Visitors: 9852
- Downloads: 45
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 512 KB | Adobe Acrobat PDF | View Details Download |