- Title
- Defining the role of the hypothalamic-pituitary-adrenal axis in the relationship between fetal growth and adult cardiometabolic outcomes
- Creator
- Martin, Wrivu N.; Wang, Carol A.; Lye, Stephen J.; Reynolds, Rebecca M.; Matthews, Stephen G.; McLaughlin, Carly E.; Oldmeadow, Christopher; Mori, Trevor A.; Beilin, Lawrence; Smith, Roger; Pennell, Craig E.
- Relation
- Journal of Developmental Origins of Health and Disease Vol. 13, Issue 6, p. 683-694
- Publisher Link
- http://dx.doi.org/10.1017/S2040174422000186
- Publisher
- Cambridge University Press
- Resource Type
- journal article
- Date
- 2022
- Description
- Animal and human data demonstrate independent relationships between fetal growth, hypothalamic-pituitary-adrenal axis function (HPA-A) and adult cardiometabolic outcomes. While the association between fetal growth and adult cardiometabolic outcomes is well-established, the role of the HPA-A in these relationships is unclear. This study aims to determine whether HPA-A function mediates or moderates this relationship. Approximately 2900 pregnant women were recruited between 1989-1991 in the Raine Study. Detailed anthropometric data was collected at birth (per cent optimal birthweight [POBW]). The Trier Social Stress Test was administered to the offspring (Generation 2; Gen2) at 18 years; HPA-A responses were determined (reactive responders [RR], anticipatory responders [AR] and non-responders [NR]). Cardiometabolic parameters (BMI, systolic BP [sBP] and LDL cholesterol) were measured at 20 years. Regression modelling demonstrated linear associations between POBW and BMI and sBP; quadratic associations were observed for LDL cholesterol. For every 10% increase in POBW, there was a 0.54 unit increase in BMI (standard error [SE] 0.15) and a 0.65 unit decrease in sBP (SE 0.34). The interaction between participant’s fetal growth and HPA-A phenotype was strongest for sBP in young adulthood. Interactions for BMI and LDL-C were non-significant. Decomposition of the total effect revealed no causal evidence of mediation or moderation.
- Subject
- hypothalamic-pituitary-adrenal axis; DoHAD; fetal growth; cardiometabolic; Trier Social Stress Test
- Identifier
- http://hdl.handle.net/1959.13/1482008
- Identifier
- uon:50835
- Identifier
- ISSN:2040-1744
- Rights
- © The Author(s), 2022. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Language
- eng
- Full Text
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