- Title
- Targeting the two-pore channel 2 in cancer progression and metastasis
- Creator
- Skelding, Kathryn A.; Barry, Daniel L.; Theron, Danielle Z.; Lincz, Lisa F.
- Relation
- Exploration of Targeted Anti-tumor Therapy Vol. 3, Issue 28 February 2022, p. 62-89
- Publisher Link
- http://dx.doi.org/10.37349/etat.2022.00072
- Publisher
- Open Exploration
- Resource Type
- journal article
- Date
- 2022
- Description
- The importance of Ca2+ signaling, and particularly Ca2+ channels, in key events of cancer cell function such as proliferation, metastasis, autophagy and angiogenesis, has recently begun to be appreciated. Of particular note are two-pore channels (TPCs), a group of recently identified Ca2+-channels, located within the endolysosomal system. TPC2 has recently emerged as an intracellular ion channel of significant pathophysiological relevance, specifically in cancer, and interest in its role as an anti-cancer drug target has begun to be explored. Herein, an overview of the cancer-related functions of TPC2 and a discussion of its potential as a target for therapeutic intervention, including a summary of clinical trials examining the TPC2 inhibitors, naringenin, tetrandrine, and verapamil for the treatment of various cancers is provided.
- Subject
- two-pore channel 2; TPCN2; tetrandrine; naringenin; cancer; anti-cancer drugs; verapamil; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1485770
- Identifier
- uon:51695
- Identifier
- ISSN:2692-3114
- Rights
- © The Author(s) 2022. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Language
- eng
- Full Text
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