- Title
- Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function
- Creator
- Kelly, Conagh J.; Chu, Matthew; Untaru, Rossana; Assadi-Khansari, Bahador; Chen, Dongqing; Croft, Amanda J.; Horowitz, John D.; Boyle, Andrew J.; Sverdlov, Aaron L.; Ngo, Doan T. M.
- Relation
- Journal of Cardiovascular Development and Disease Vol. 10, Issue 7, no. 274
- Publisher Link
- http://dx.doi.org/10.3390/jcdd10070274
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2023
- Description
- Secreted frizzled-related protein 5 (SFRP5) is a novel anti-inflammatory adipokine that may play a role in cardiovascular development and disease. However, there is yet to be a comprehensive investigation into whether circulating SFRP5 can be a biomarker for cardiac function. Plasma SFRP5 levels were measured via ELISA in 262 patients admitted to a cardiology unit. Plasma SFRP5 levels were significantly lower in patients with a history of heart failure (HF), coronary artery disease (CAD), and atrial fibrillation (AF; p = 0.001). In univariate analyses, SFRP5 levels were also significantly positively correlated with left ventricular ejection fraction (LVEF) (r = 0.52, p < 0.001) and negatively correlated with E/E’ (r = −0.30, p < 0.001). Patients with HF, CAD, low LVEF, low triglycerides, high CRP, and high eGFR were associated with lower SFRP5 levels independent of age, BMI, or diabetes after multivariate analysis (overall model r = 0.729, SE = 0.638). Our results show that low plasma SFRP5 levels are independently associated with the presence of HF, CAD, and, importantly, impaired LV function. These results suggest a potential role of SFRP5 as a biomarker, as well as a mediator of cardiac dysfunction independent of obesity and metabolic regulation.
- Subject
- secreted frizzled-related protein 5 (SFRP5); heart failure; cardiovascular function; coronary artery disease; obesity; cardiovascular disease
- Identifier
- http://hdl.handle.net/1959.13/1487863
- Identifier
- uon:52280
- Identifier
- ISSN:2308-3425
- Rights
- x
- Language
- eng
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