- Title
- Adverse pregnancy outcomes are associated with shorter telomere length in the 17-year-old child
- Creator
- Bianco-Miotto, Tina; Phillips, Aaron L.; Heinze, Dale R.; Pennell, Craig E.; Maganga, Richard K.; Beilin, Lawrence J.; Mori, Trevor A.; Grieger, Jessica A.
- Relation
- Journal of Developmental Origins of Health and Disease Vol. 15, no. e26
- Publisher Link
- http://dx.doi.org/10.1017/S2040174424000291
- Publisher
- Cambridge University Press
- Resource Type
- journal article
- Date
- 2024
- Description
- This study examined associations between pregnancy and infant birth outcomes with child telomere length at age 17 years; and investigated if there are sex differences between pregnancy complications and telomere length. We utilised the population-based prospective Raine cohort study in Western Australia, Australia. 2900 pregnant women were recruited at 16-20 weeks' gestation (Gen 1), and their children (Gen 2) were followed up over several years. Generalised linear models were used to examine relationships between pregnancy or birth outcomes (gestational diabetes, pre-eclampsia, preterm birth, low birth weight, macrosomia), and as a composite, with telomere length, measured via a DNA sample from blood at 17 years of age. Analyses were adjusted for a range of confounders. Among the 1202 included children, there were no differences in child telomere length for any of the individual maternal or birth weight pregnancy outcomes nor were there any significant interactions between each of the complications (individual or composite) and the sex of the child. However, females born from any of the 5 adverse outcomes had shorter telomeres (estimated mean (SE) = -0.159 (0.061), p = 0.010) than females born in the absence of these complications. Specifically, females born from a pre-eclamptic pregnancy had shorter telomeres than females not born from a pre-eclamptic pregnancy (estimated mean (SE) = -0.166 (0.072), p = 0.022). No relationships were observed in males. Further longitudinal studies are needed to understand mediating factors that are important in predicting offspring telomere length and the necessity to investigate females and males independently.
- Subject
- Raine study; telomere length; pregnancy complication; pre-eclampsia; longitudinal; SDG 3; Sustainable Development Goal
- Identifier
- http://hdl.handle.net/1959.13/1516788
- Identifier
- uon:57024
- Identifier
- ISSN:2040-1744
- Rights
- This is an open access article distributed under the terms of the Creative Commons CC BY license (https://creativecommons.org/licenses/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Language
- eng
- Full Text
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