- Title
- Shared genetic architecture between gastro-esophageal reflux disease, asthma, and allergic diseases
- Creator
- Gong, Tong; Kuja-Halkola, Ralf; Almqvist, Catarina; Brew, Bronwyn K.; Harder, Arvid; Lundholm, Cecilia; Smew, Awad I.; Lehto, Kelli; Andreasson, Anna; Lu, Yi; Talley, Nicholas J.; Pasman, Joëlle A.
- Relation
- Communications Biology Vol. 7, no. 1077 (2024)
- Publisher Link
- http://dx.doi.org/10.1038/s42003-024-06795-1
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2024
- Description
- The aim is to investigate the evidence for shared genetic architecture between each of asthma, allergic rhinitis and eczema with gastro-esophageal reflux disease (GERD). Structural equation models (SEM) and polygenic risk score (PRS) analyses are applied to three Swedish twin cohorts (n = 46,582) and reveal a modest genetic correlation between GERD and asthma of 0.18 and bidirectional PRS and phenotypic associations ranging between OR 1.09-1.14 and no correlations for eczema and allergic rhinitis. Linkage disequilibrium score regression is applied to summary statistics of recently published GERD and asthma/allergic disease genome wide association studies and reveals a genetic correlation of 0.48 for asthma and GERD, and Genomic SEM supports a single latent factor. A gene-/gene-set analysis using MAGMA reveals six pleiotropic genes (two at 12q13.2) associated with asthma and GERD. This study provides evidence that there is a common genetic architecture unique to asthma and GERD that may explain comorbidity and requires further investigation.
- Subject
- allergy; asthma; gastro-oesophageal reflux disease; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1518000
- Identifier
- uon:57209
- Identifier
- ISSN:2399-3642
- Rights
- x
- Language
- eng
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