Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

- Evangelou, Evangelos; Warren, Helen R.; Ng, Fu Liang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N.; Giri, Ayush; Velez Edwards, Digna R.; Sun, Yan V.; Cho, Kelly; Gaziano, J. Michael; Mosen-Ansorena, David; Wilson, Peter W. F.; Tsao, PS; Kovesdy, CP; Esko, T; Mägi, R; Milani, L; Almgren, P; Boutin, T; Debette, S; Ding, J; Mifsud, Borbala; Giulianini, F; Holliday, Elizabeth G.; Jackson, AU; Li-Gao, R; Lin, WY; Luan, J; Mangino, M; Oldmeadow, Christopher; Attia, John R.; Qian, Y; Pazoki, Raha; Sargurupremraj, M; Shah, N; Surendran, P; Thériault, S; Verweij, N; Willems, SM; Zhao, JH; Amouyel, P; Connell, J; de Mutsert, R; Gao, He; Doney, ASF; Farrall, M; Menni, C; Morris, AD; Noordam, R; Paré, G; Poulter, NR; Shields, DC; Stanton, A; Thom, S; Ntritsos, Georgios; Abecasis, G; Amin, N; Arking, DE; Ayers, KL; Barbieri, CM; Batini, C; Bis, JC; Blake, T; Bochud, M; Boehnke, M; Dimou, Niki; Boerwinkle, E; Boomsma, DI; Bottinger, EP; Braund, PS; Brumat, M; Campbell, A; Campbell, H; Chakravarti, A; Chambers, JC; Cabrera, Claudia P.; Karaman, Ibrahim

Title
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
Creator
Evangelou, Evangelos; Warren, Helen R.; Ng, Fu Liang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N.; Giri, Ayush; Velez Edwards, Digna R.; Sun, Yan V.; Cho, Kelly; Gaziano, J. Michael; Mosen-Ansorena, David; Wilson, Peter W. F.; Tsao, PS; Kovesdy, CP; Esko, T; Mägi, R; Milani, L; Almgren, P; Boutin, T; Debette, S; Ding, J; Mifsud, Borbala; Giulianini, F; Holliday, Elizabeth G.; Jackson, AU; Li-Gao, R; Lin, WY; Luan, J; Mangino, M; Oldmeadow, Christopher; Attia, John R.; Qian, Y; Pazoki, Raha; Sargurupremraj, M; Shah, N; Surendran, P; Thériault, S; Verweij, N; Willems, SM; Zhao, JH; Amouyel, P; Connell, J; de Mutsert, R; Gao, He; Doney, ASF; Farrall, M; Menni, C; Morris, AD; Noordam, R; Paré, G; Poulter, NR; Shields, DC; Stanton, A; Thom, S; Ntritsos, Georgios; Abecasis, G; Amin, N; Arking, DE; Ayers, KL; Barbieri, CM; Batini, C; Bis, JC; Blake, T; Bochud, M; Boehnke, M; Dimou, Niki; Boerwinkle, E; Boomsma, DI; Bottinger, EP; Braund, PS; Brumat, M; Campbell, A; Campbell, H; Chakravarti, A; Chambers, JC; Cabrera, Claudia P.; Karaman, Ibrahim
Relation
Nature Genetics Vol. 50, p. 1412-1425
Publisher Link
http://dx.doi.org/10.1038/s41588-018-0205-x
Publisher
Nature Publishing Group
Resource Type
journal article
Date
2018
Description
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
Subject
high blood pressure; cardiovascular disease; blood pressure; genetic association; SDG 3; Sustainable Development Goals
Identifier
http://hdl.handle.net/1959.13/1450999
Identifier
uon:44073
Identifier
ISSN:1061-4036
Language
eng
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