The Promise of Single-cell Technology in Providing New Insights into the Molecular Heterogeneity and Management of Acute Lymphoblastic Leukemia
- Creator: Pearson, Holly C. L. , Hunt, Kooper V. , Trahair, Toby N. , Lock, Richard B. , Lee, Heather J. , de Bock, Charles E.
- Resource Type: journal article
- Date: 2022
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells
- Creator: Tremblay, Cedric S. , Chiu, Sung Kai , Saw, Jesslyn , McCalmont, Hannah , Litalien, Veronique , Boyle, Jacqueline , Sonderegger, Stefan E. , Chau, Ngoc , Evans, Kathryn , Cerruti, Loretta , Salmon, Jessica M. , McCluskey, Adam , Lock, Richard B. , Robinson, Phillip J. , Jane, Stephen M. , Curtis, David J.
- Resource Type: journal article
- Date: 2020
A Menin-MLL inhibitor induces specific chromatin changes and eradicates disease in models of MLL-rearranged leukemia
- Creator: Krivtsov, Andrei V. , Evans, Kathryn , McDermott, Lisa , Jones, Connor D. , Jing, Duohui , Braytee, Ali , Chacon, Diego , Earley, Eric , McKeever, Brian M. , Claremon, David , Gifford, Andrew J. , Lee, Heather J. , Gadrey, Jayant Y. , Teicher, Beverley A. , Pimanda, John E. , Beck, Dominik , Perry, Jennifer A. , Smith, Malcolm A. , McGeehan, Gerard M. , Lock, Richard B. , Armstrong, Scott A. , Eschle, Benjamin K. , Hatton, Charlie , Uckelmann, Hannah J. , Ross, Kenneth N. , Perner, Florian , Olsen, Sarah N. , Pritchard, Tara
- Resource Type: journal article
- Date: 2019
T-cell acute lymphoblastic leukemia express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development
- Creator: de Bock, Charles E. , Down, Michelle , Baidya, Kinsha , Sweron, Bram , Boyd, Andrew W. , Fiers, Mark , Burns, Gordon F. , Molloy, Timothy J. , Lock, Richard B. , Soulier, Jean , Taghon, Tom , Van Vlierberghe, Pieter , Cools, Jan , Holst, Jeff , Thorne, Rick F.
- Resource Type: journal article
- Date: 2019
Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors
- Creator: Smith, Amanda M. , Dun, Matthew D. , Toop, Hamish , Lock, Richard B. , Powell, Jason A. , Thomas, Daniel , Guthridge, Mark A. , Moore, Andrew , Ashman, Leonie K. , Skelding, Kathryn A. , Enjeti, Anoop , Verrills, Nicole M. , Lee, Erwin M. , Harrison, Celeste , Kahl, Richard , Flanagan, Hayley , Panicker, Nikita , Mashkani, Baratali , Don, Anthony S. , Morris, Jonathan
- Resource Type: journal article
- Date: 2016
Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1
- Creator: Shahbazi, Jeyran , Scarlett, Christopher J. , Lock, Richard B. , Liu, Tao , Norris, Murray D. , Liu, Bing , Haber, Michelle , Tee, Andrew E. , Carrier, Alice , Biankin, Aandrew V. , London, Wendy B. , Marshall, Glenn M.
- Resource Type: journal article
- Date: 2014
Proteomic analysis reveals a novel role for the actin cytoskeleton in vincristine resistant childhood leukemia: an in vivo study
- Creator: Verrills, Nicole M. , Liem, Natalia L. , Liaw, Tracey Y. E. , Hood, Brian D. , Lock, Richard B. , Kavallaris, Maria
- Resource Type: journal article
- Date: 2006