https://novaprd-lb.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 A novel MMP12 locus Is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:16959 -7), with independent replication in a second population (p = 0.0048, OR(95% CI) = 1.18(1.05–1.32); meta-analysis p = 2.6×10-8). The nearby gene, MMP12, was significantly over expressed in carotid plaques compared to atherosclerosis-free control arteries (p = 1.2×10-15; fold change = 335.6). Permutation analyses demonstrated improved significance for associations when accounting for age-at-onset in all four stroke phenotypes (p<0.001). Our results show that a covariate-informed design, by adjusting for age-at-onset of stroke, can detect variants not identified by conventional GWAS.]]> Wed 11 Apr 2018 17:21:31 AEST ]]> Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12 https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:20390 Wed 11 Apr 2018 16:32:40 AEST ]]> Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:18827 Wed 11 Apr 2018 13:01:16 AEST ]]> No additional prognostic value of genetic information in the prediction of vascular events after cerebral ischemia of arterial origin: The PROMISe study https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:28417 Wed 11 Apr 2018 11:52:24 AEST ]]>