https://novaprd-lb.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:13674 Wed 24 Jun 2020 12:51:30 AEST ]]> Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:13672 Wed 11 Apr 2018 16:23:10 AEST ]]> Comparing genotyping algorithms for Illumina's Infinium whole-genome SNP BeadChips https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:13673 Wed 11 Apr 2018 15:24:43 AEST ]]> A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:9503 Wed 11 Apr 2018 13:47:54 AEST ]]> The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:9594 Sat 24 Mar 2018 08:39:37 AEDT ]]> Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:12845 T at 3p24.1 (odds ratio [OR], 1.17; p = 1.6 × 10−8) near EOMES, rs2150702G in the second intron of MLANA on chromosome 9p24.1 (OR, 1.16; p = 3.3 × 10−8), and rs6718520A in an intergenic region on chromosome 2p21, with THADA as the nearest flanking gene (OR, 1.17; p = 3.4 × 10−8). The 3 new loci do not have a strong cis effect on RNA expression in PBMCs. Ten other susceptibility loci had a suggestive p < 1 × 10−6, some of these loci have evidence of association in other inflammatory diseases (ie, IL12B, TAGAP, PLEK, and ZMIZ1). Interpretation: We have performed a meta-analysis of GWAS in MS that more than doubles the size of previous gene discovery efforts and highlights 3 novel MS susceptibility loci. These and additional loci with suggestive evidence of association are excellent candidates for further investigations to refine and validate their role in the genetic architecture of MS.]]> Sat 24 Mar 2018 08:17:22 AEDT ]]> Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:25354 Sat 24 Mar 2018 07:24:42 AEDT ]]>