https://novaprd-lb.newcastle.edu.au/vital/access/manager/Index en-au 5 Genome-wide association and functional follow-up reveals new loci for kidney function https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:15141 Wed 11 Apr 2018 13:54:12 AEST ]]> Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:34209 Wed 09 Feb 2022 15:53:11 AEDT ]]> Exome-derived adiponectin-associated variants implicate obesity and lipid biology https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:41704 -7). Comparison of exome array variants to regional linkage disequilibrium (LD) patterns and prior genome-wide association study (GWAS) results detected candidate variants (r2 > .60) spanning as much as 900 kb. To identify potential genes and mechanisms through which the previously unreported association signals act to affect adiponectin levels, we assessed cross-trait associations, expression quantitative trait loci in subcutaneous adipose, and biological pathways of nearby genes. Eight of the nine loci were also associated (p < 1 x 10-4) with at least one obesity or lipid trait. Candidate genes include PRKAR2A, PTH1R, and HDAC9, which have been suggested to play roles in adipocyte differentiation or bone marrow adipose tissue. Taken together, these findings provide further insights into the processes that influence circulating adiponectin levels.]]> Thu 11 Aug 2022 15:21:17 AEST ]]> Genome-wide association study of kidney function decline in individuals of European descent. https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:17347 Sat 24 Mar 2018 08:01:42 AEDT ]]>