https://novaprd-lb.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:38111 [BI] = 9.38 × 10-25; p[SSBI] = 5.23 × 10-14 for hypertension), smoking (p[BI]= 4.4 × 10-10; p[SSBI] = 1.2 × 10-4), diabetes (p[BI] = 1.7 × 10 -8; p[SSBI] = 2.8 × 10-3), previous cardiovascular disease (p[BI] = 1.0 × 10-18; p[SSBI] = 2.3 × 10-7), stroke (p[BI] = 3.9 × 10-69; p[SSBI] = 3.2 × 10-24), and MRI-defined white matter hyperintensity burden (p[BI]=1.43 × 10-157; p[SSBI] = 3.16 × 10-106), but not with body mass index or cholesterol. GRS of BP traits were associated with BI and SSBI (p = 0.0022), without indication of directional pleiotropy. Conclusion: In this multiethnic GWAS meta-analysis, including over 20,000 population-based participants, we identified genetic risk loci for BI requiring validation once additional large datasets become available. High BP, including genetically determined, was the most significant modifiable, causal risk factor for BI.]]> Wed 04 Aug 2021 10:54:18 AEST ]]> Attenuated glycine receptor function reduces excitability of mouse medial vestibular nucleus neurons https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:11329 Sat 24 Mar 2018 08:12:34 AEDT ]]> Probing glycine receptor stoichiometry in superficial dorsal horn neurones using the spasmodic mouse https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:17904 Sat 24 Mar 2018 07:56:40 AEDT ]]> Altered inhibitory synaptic transmission in superficial dorsal horn neurones in spastic and oscillator mice https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:5822 Sat 24 Mar 2018 07:48:01 AEDT ]]> Altered potassium channel function in the superficial dorsal horn of the spastic mouse https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:5793 Sat 24 Mar 2018 07:44:56 AEDT ]]> Australian Brain Alliance https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:29063 Sat 24 Mar 2018 07:40:08 AEDT ]]> Intrinsic and synaptic homeostatic plasticity in motoneurons from mice with glycine receptor mutations https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:16907 A miniature inhibitory postsynaptic current (mIPSC) amplitude was increased in spa and ot but not spd, suggesting diminished glycinergic drive leads to compensatory adjustments in the other major fast inhibitory synaptic transmitter system in these mutants. Overall, our data suggest long-term reduction in glycinergic drive to HMs results in changes in intrinsic and synaptic properties that are consistent with homeostatic plasticity in spa and ot but not in spd. We propose such plasticity is an attempt to stabilize HM output, which succeeds in spa but fails in ot.]]> Mon 30 Sep 2019 12:26:58 AEST ]]>