https://novaprd-lb.newcastle.edu.au/vital/access/manager/Index en-au 5 Significance of cerebral small-vessel disease in acute intracerebral hemorrhage https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:24519 Wed 09 Mar 2022 16:03:44 AEDT ]]> Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:25277 −11; odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28–1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes.]]> Sat 24 Mar 2018 07:38:17 AEDT ]]> Recommendations from the international stroke genetics consortium, part 1: standardized phenotypic data collection https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:27208 Sat 24 Mar 2018 07:32:26 AEDT ]]> Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:30052 -8; joint OR 1·19, 1·12-1·26, p=1·30 × 10-9). Our results also supported robust associations with ischaemic stroke for four other loci that have been reported in previous studies, including PITX2 (first stage OR 1·39, 1·29-1·49, p=3·26 × 10-19; joint OR 1·37, 1·30-1·45, p=2·79 × 10-32) and ZFHX3 (first stage OR 1·19, 1·11-1·27, p=2·93 × 10-7; joint OR 1·17, 1·11-1·23, p=2·29 × 10-10) for cardioembolic stroke, and HDAC9 (first stage OR 1·29, 1·18-1·42, p=3·50 × 10-8; joint OR 1·24, 1·15-1·33, p=4·52 × 10-9) for large artery atherosclerosis stroke. The 12q24 locus near ALDH2, which has previously been associated with all ischaemic stroke but not with any specific subtype, exceeded genome-wide significance in the meta-analysis of small artery stroke (first stage OR 1·20, 1·12-1·28, p=6·82 × 10-8; joint OR 1·17, 1·11-1·23, p=2·92 × 10-9). Other loci associated with stroke in previous studies, including NINJ2, were not confirmed. Interpretation: Our results suggest that all ischaemic stroke-related loci previously implicated by GWAS are subtype specific. We identified a novel gene associated with large artery atherosclerosis stroke susceptibility.]]> Sat 24 Mar 2018 07:31:15 AEDT ]]> Genome-wide association meta-analysis of functional outcome after ischemic stroke https://novaprd-lb.newcastle.edu.au/vital/access/manager/Repository/uon:48737 Fri 31 Mar 2023 16:23:23 AEDT ]]>